Gene overexpression increased from low- to high-grade lesions to cancer.

2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Gene overexpression increased from low- to high-grade lesions to cervical cancer.

"The Pap test has effectively reduced the incidence and mortality of cervical cancer," investigators in the United States report.

"However, because of the morphological basis of this test, sensitivity and specificity are less than ideal, a situation that complicates the clinical management of women diagnosed with low-grade cervical abnormalities," wrote Y. Chen and colleagues, Millennium Pharmaceuticals, Inc., Department of Cell & Molecular Biology.

"In an attempt to understand the molecular basis of cervical tumorigenesis and …